Medium Flow Device for ECCO2R Treatments

  • Unique Medium Flow device up to 800ml/min of blood flow
  • Designed to treat COPD (Chronic Obstructive Pulmonary Disease) Patients and mild/moderate ARDS (Acute Respiratory Distress Syndrome) Patients
  • ECCO2R circuit validated 5 DAYS
  • Possibility to carry out hemofiltration procedure in parallel (Patented solution)
  • V’CO2ML (amount of carbon dioxide removed by Membrane Lung) real time monitoring
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CO2RESET machine is designed for ECCO2R procedures in COPD and mild-severe ARDS Patients, to minimize respiratory acidosis while applying an ultra-protective ventilatory strategy.

Mechanical ventilation (MV) is a potentially life-saving intervention in Patients with severe respiratory insufficiency when spontaneous breathing is inadequate to maintain effective gas exchange1. Nevertheless, there are numerous detrimental consequences of Mechanical ventilation MV.

These include lung over-inflation, oxygen toxicity, right ventricular failure and ventilator- associated pneumonia (VAP). The adverse effects of MV have a profound impact on the morbidity and mortality of patient with severe respiratory failure.

Many investigators demonstrated that limiting tidal volume (VT) to 6 mL/kg of predicted body weight (PBW) and end-inspiratory plateau pressure (PPLAT) to ≤ 30 cmH2O improves survival3, but in some patients these settings may not be fully protective.

Reduction of tidal volume (VT) to 3–4 mL/kg and PPLAT≤25 cmH2O has been proposed to further minimize the risk of VILI6, but this entails a significant risk of severe respiratory acidosis.

The importance of monitoring V’CO2ML

CO2RESET device can minimize acidosis by clearing carbon dioxide (CO2) thanks to a dedicated membrane oxygenator, also defined as Membrane Lung (ML). The amount of carbon dioxide removed (V’CO2ML) is continuously shown on the display in real time. In this way, less CO2 has to be eliminated from the lungs enabling strategies that are more lung protective.

Such strategies might improve outcomes by: using VT as low as 3-4 mL/kg and further decreasing PPLAT below 30 cmH2O (often defined ultra-protective strategy)  decreasing respiratory rates minimizing driving pressures or mechanical power.
Blood flow
100-800 ml/min
Max Gas Flow/Blood Flow Ratio
Blood Inlet
1/4 (6.35 mm)
Blood Outlet
1/4 (6.35 mm)
Gas Inlet
1/4 (6.35 mm)
Gas Outlet
3/8 (9.53 mm)
Priming Volume
130 ml
Membrane Type
Polymethylpentene (PMP)
Phosphorylcholine (PC)
Membrane Surface Area
1.81 m2

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